Glomerular filtration rate determined by radionuclide method and pitfalls worth notice / 中华检验医学杂志

ABSTRACT

Glomerular filtration rate(GFR)can be calculated either by radionuclide technology or by dynamic renal scintillation.The latter technique is simple and practical,and provides serial measurement of renal blood flow and excretion images in addition to estimate GFR and other renal parameters.GFR assessed with this method usually coincides with clinical diagnosis and correlates with GFR value determined by other methodology.GFR determined by radionuclide imaging may result in significant bias or be indeterminate due to many influencing factors such as inaccurate measurement of radioactivity,misconduct of "bolus" injection,irregular body shape and varied kidney locations,severities of renal conditions,and extra- renal interference,soft-ware proceeding methods and technician's skills,etc.It is worth notice that,in clinic,renal parameters other than GFR should be taken into account for full evaluation of renal function status.