A case report of chronic granulomatous disease presenting with aspergillus pneumonia in a 2-month old girl / 소아과
Korean Journal of Pediatrics
;
: 722-726, 2010.
Article
in English
| WPRIM
| ID: wpr-59050
ABSTRACT
Chronic granulomatous disease (CGD) is an uncommon inherited disorder caused by mutations in any of the genes encoding subunits of the superoxide-generating phagocyte NADPH oxidase system, which is essential for killing catalase producing bacteria and fungi, such as Aspergillus species, Staphylococcus aureus, Serratia marcescens, Nocardia species and Burkholderia cepacia. In case of a history of recurrent or persistent infections, immune deficiency should be investigated. Particularly, in the case of uncommon infections such as aspergillosis in early life, CGD should be considered. We describe here a case of CGD that presented with invasive pulmonary aspergillosis in a 2-month-old girl. We confirmed pulmonary aspergillosis noninvasively through a positive result from the culture of bronchial alveolar lavage fluid, positive serological test for Aspergillus antigen and radiology results. She was successfully treated with Amphotericin B and recombinant IFN-gamma initially. Six weeks later after discharge, she was readmitted for pneumonia. Since there were infiltrates on the right lower lung, which were considered as residual lesions, voriconazole therapy was initiated. She showed a favorable response to the treatment and follow-up CT showed regression of the pulmonary infiltrates.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phagocytes
/
Pneumonia
/
Pyrimidines
/
Aspergillosis
/
Aspergillus
/
Serratia marcescens
/
Staphylococcus aureus
/
Bacteria
/
Triazoles
/
Serologic Tests
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
/
Infant
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2010
Type:
Article
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