Antioxidation of Chondrus yendoi and its protective effect on mitochondria / 中国海洋药物
Chinese Journal of Marine Drugs
;
(6)2000.
Article
in Chinese
| WPRIM
| ID: wpr-590540
ABSTRACT
Objective To investigate if Chondrus yendoi decoction(CYD) and polysaccharide(CYP) have the effects of scavenging superoxide anion(O?—2),antioxidation,protecting mitochondria from damage.Methods Lipid peroxidation and swelling of mouse liver and brain mitochondria were induced by Fe2+-L-Cys system in vitro.Superoxide anion was generated by reduced nicotinamide adenine dinucleotide(NADH)-N-methylphenazonium methyl sulfate(PMS)-4-nitrobluetetrazolium chloride(NBT) system.Lipid peroxide malondialdehyde(MDA),mitochondrial swelling and superoxide anion formation were determined by spectrophotometry.Results CYD and CYP could inhibit MDA production,protect mitochondria from swelling,and scavenge O?-2 obviously in a dose-dependent manner.Conclusion CYD and CYP had the effects of scavenging O?-2,antioxidation,protecting mitochondria from injury.CYP was the major bioactive component.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Marine Drugs
Year:
2000
Type:
Article
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