Role of transcription regulatory factor ETS-1 in angiogenesis / 中国组织工程研究

ABSTRACT

BACKGROUND:ETS-1,the first subgroup in the ETS family transcription factor,plays a key role in angiogenesis.Recent studies demonstrate that ETS-1 also has the important regulative functions in apoptosis of vascular endothelial cells.When the blood vessel begins to form,ETS-1 decides the apoptosis of partial endothelial cells.OBJECTIVE:To summarize the function and the research progress of vascular growth factor ETS-1 in angiogenesis and apoptosis.RETRIEVAL STRATEGYA computer-based search in Pubmed,Sciencedirect and Ovid database was underwent to identify the articles from January 1990 to September 2007,with the Key word "ETS-1,angiogenesis,apoptosis,osteoblast,osteoclast" in English.Simultaneously,Chinese Journal Full-text Database and Wanfang database were retrieved for the related articles from January 2000 to June 2007,with the key word "ETS-1,angiogenesis,apoptosis,endothelial cell" in Chinese.Altogether 128 articles were collected and carried on the first examination.Inclusive criteria①The articles closely correlated with ETS-1 in angiogenesis and apoptosis.②The articles published recently or in the authoritative magazine were chose for the identical domain.Exclusive criteriaDuplicated researches.LITERATURE EVALUATIONThe articles were mainly the experimental study of EST-1 in angiogenesis and apoptosis.Among 31 selected articles,2 were reviews while other 29 for clinical or basic experimental studies.DATA SYNTHESIS:①When orthodontic tooth moves,alveolar bone rebuilding is the dynamical equilibrium process between bone absorption and new bone formation.This process mechanism is complex and adjusted by many kinds of factors.②Among numerous regulatory factors,ETS-1 is the dominant factor and has important effect on angiogenesis.③The research indicates,four kinds of typical vascular growth factors(acid fibroblast growth factor,basic fibroblast growth factor,vascular endothelial growth factor and epidermal growth factor) can induce the ETS-1 expression,and ETS-1 promotes vessel production through inducing the expressions of the related factors with angiogenesis,such as matrix metalloproteinase and integrin ?3.④Many progresses have been achieved in the regulatory effect of ETS-1 in angiogenesis,but it still has many problems,such as how the ETS-1 precisely regulate angiogenesis,how the ETS-1 precisely adjust apoptosis in gene expression and so on.CONCLUSION:As a kind of important regulatory factors,ETS-1 has important regulatory effects on angiogenesis and apoptosis.