Expression of survivin in nasal-NK/T cell lymphoma and its correlation with caspase-3 and ki-67 / 医学研究生学报

ABSTRACT

Objective: To investigate the expression of survivin in nasal-NK/T cell lymphoma,and to analyze the relationship of the expression with caspase-3 and cell proliferation.Methods: We detected the expressions of survivin,caspase-3 and ki-67 by immunohistochemical EnVision System in 50 cases of nasal-NK/T cell lymphoma and 12 normal lymph nodes,and analyzed the correlation of the survivin gene in the tumor tissues with the caspase-3 gene and ki-67 proliferation.Results: The positive expression rate of survivin was 60%(30/50) in the tumor tissues and 16.7%(2/12) in the normal lymph nodes,with significant differences between the 2 groups(P0.05).The ki-67 proliferation index was significantly higher in the survivin-positive lymphomas(38.23?16.54)% than in the survivin-negative ones.The high expression of the survivin gene was closely correlated with the down-regulation of the caspase-3 gene.Conclusion: survivin may prevent cell apoptosis by inhibiting the activity of caspase-3 play an important role in the carcinogenesis of NK/T cell lymphomas by promoting cell proliferating.