Relationship between anti-Hp-IgG seroprevalence and HBV load and HBV genotypes in patients with chronic hepatitis B / 吉林大学学报(医学版)

ABSTRACT

Objective To research the role of Helicobacter pylori(Hp) on chronic hepatitis B.Methods The seroprevalence of Hp infection and the quantity and genotyping of HBV DNA in 376 patients with chronic hepatitis B,including chronichepatitis group,cirrhosis group and HBV-related hepatocellular carcinoma(HCC) group,were detected,and compared with control and gastritis groups.Results Hp seropositivities in chronic hepatitis B group(56.2%),cirrhosis group(69.9%),HCC group(75.0%) were higher than that in control group(43.4%)(P0.05),the Hp seropositivities in cirrhosis and HCC groups were higher than that in chronic hepatitis group(P0.05).Conclusion Seroprevalence of antibodies to Hp in patients with chronic hepatitis B increases significantly,and Hp seropositivity increases with the pathological changes of chronic hepatitis B.