Dura mater substitutes / 中国组织工程研究

ABSTRACT

Cerebral dura mater substitutes for dural repair are essential to maintain anatomical integrity and cerebral protection. Currently, there are three substitutes of cerebral dura mater including xenograft (bovine pericardium), allograft (cadaver cerebral dura mater) and synthesized material (expended polytetrafluoroethylene). Each material has their specific advantages, accompanied by some drawbacks. For example, autologous membrane material has limited sources and worse intensity than natural dura mater, and may induce secondary trauma; allogenous membrane can cause viral infection; xenogenous membrane has residual toxicity after glutaral processing; gelatin sponge has rapid degradation, but its intensity is bad and unable to suture. The synthesized material based on allogenous and xenogenous materials may be developed by the combination of their specific advantages.