Research progress on the DNA vaccine of HSP70 fused with tumor antigen gene / 基础医学与临床

ABSTRACT

A variety of heat shock protein 70(HSP70)-associated therapeutic vaccines including protein vaccine,peptide vaccine,tumor cell vaccine and DNA vaccine,have been developed and applied in anti-tumor immunotherapy,in which HSP70-fused DNA vaccine attracts our attention with its superiority.It not only induces consistent anti-tumor immune response but also helps sustain immune memory.In this article we reviewed the function and application of HSP70 in the therapeutic tumor DNA vaccine.