Mechanisms on The Regulation of miRNAs Expression / 生物化学与生物物理进展
Progress in Biochemistry and Biophysics
;
(12)2006.
Article
in Chinese
| WPRIM
| ID: wpr-591697
ABSTRACT
MicroRNAs(miRNAs),small noncoding RNAs,are essential for posttranscriptional gene regulation and have important roles in a wide range of biological processes,including development,growth and differentiation. Thousands of miRNAs have been identified in animals,plants and microoaganisms. miRNAs regulate their target genes by mRNA degradation or translation suppression. About 30 % of genes in an organism are subject to miRNA regulation. miRNA expression and function are regulated by transcriptional factors,epigenetics,single nucleotide polymorphisms,RNA editing and so on. Additionally,the success in knocking out a specific mouse miRNA gene has provided a valuable model for studying miRNA function.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Progress in Biochemistry and Biophysics
Year:
2006
Type:
Article
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