Your browser doesn't support javascript.
loading
The role of renal proximal tubule transport in the regulation of blood pressure
Kidney Research and Clinical Practice ; : 12-21, 2017.
Article in English | WPRIM | ID: wpr-59172
ABSTRACT
The electrogenic sodium/bicarbonate cotransporter 1 (NBCe1) on the basolateral side of the renal proximal tubule plays a pivotal role in systemic acid-base homeostasis. Mutations in the gene encoding NBCe1 cause severe proximal renal tubular acidosis accompanied by other extrarenal symptoms. The proximal tubule reabsorbs most of the sodium filtered in the glomerulus, contributing to the regulation of plasma volume and blood pressure. NBCe1 and other sodium transporters in the proximal tubule are regulated by hormones, such as angiotensin II and insulin. Angiotensin II is probably the most important stimulator of sodium reabsorption. Proximal tubule AT(1A) receptor is crucial for the systemic pressor effect of angiotensin II. In rodents and rabbits, the effect on proximal tubule NBCe1 is biphasic; at low concentration, angiotensin II stimulates NBCe1 via PKC/cAMP/ERK, whereas at high concentration, it inhibits NBCe1 via NO/cGMP/cGKII. In contrast, in human proximal tubule, angiotensin II has a dose-dependent monophasic stimulatory effect via NO/cGMP/ERK. Insulin stimulates the proximal tubule sodium transport, which is IRS2-dependent. We found that in insulin resistance and overt diabetic nephropathy, stimulatory effect of insulin on proximal tubule transport was preserved. Our results suggest that the preserved stimulation of the proximal tubule enhances sodium reabsorption, contributing to the pathogenesis of hypertension with metabolic syndrome. We describe recent findings regarding the role of proximal tubule transport in the regulation of blood pressure, focusing on the effects of angiotensin II and insulin.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma Volume / Rodentia / Sodium / Acidosis, Renal Tubular / Blood Pressure / Insulin Resistance / Angiotensin II / Sodium-Bicarbonate Symporters / Diabetic Nephropathies / Homeostasis Limits: Animals / Humans Language: English Journal: Kidney Research and Clinical Practice Year: 2017 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Plasma Volume / Rodentia / Sodium / Acidosis, Renal Tubular / Blood Pressure / Insulin Resistance / Angiotensin II / Sodium-Bicarbonate Symporters / Diabetic Nephropathies / Homeostasis Limits: Animals / Humans Language: English Journal: Kidney Research and Clinical Practice Year: 2017 Type: Article