Effect of Ceftriaxone on glutamate-induced cerebral cortical neurocyte injury / 临床神经病学杂志
Journal of Clinical Neurology
;
(6)1993.
Article
in Chinese
| WPRIM
| ID: wpr-591983
ABSTRACT
Objective To study the effect of Ceftriaxone on glutamate-induced neurocyte injury. Methods Cultured rat cerebral cortical neurocytes were divided into Ceftriaxone (A)group, glutamate(B) group ,Ceftriaxone-pretreated (C) group and control (D) group. Observe morphous and MTT colorimetry were used to detect cytoactive. Laser scanning confocal microscope was used to measure the change of Ca2+ in rest state and after brief glutamate-induced Ca2+ loading. RT-PCR was used to determine the change of GLT1 mRNA expression.Results Compared with B group, cellular morphous was closer to normal in C group. Absorptance values of groups A,B,C,D were 0.795?0.010, 0.624?0.028, 0.738?0.021 and 0.813?0.023, respectively, which there were lower in groups B and C compared with group D, but absorptance value was higher in group C than that in group B(allP
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Clinical Neurology
Year:
1993
Type:
Article
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