Role of CD28:CTLA4/B7 costimulatory molecules in experimental autoimmune myasthenia gravis / 临床神经病学杂志

ABSTRACT

Objective To study pathogenesis role of CD28CTLA4/B7 costimulatory molecules in experimental autoimmune myasthenia gravis(EAMG). Methods Female lewis rats were divided into EAMG group and control group. The rats were immunized thrice with R?97-116 peptide in EAMG group, or only with phosphate buffer saline(PBS) in control group. 5 d after the third immunization, the expressions of CD28,CTLA4,B7-1, B7-2 on the surface of peripheral blood cells, lymphocytes and monocytes were exaimed by flow cytometry. Results In EAMG group,the achievement ratio of EAMG model was 75%; the expressions of CD28,CTLA4,B7-1, B7-2 on the surface of peripheral blood cells were significantly increased than those in control group (P