Relationship between Serum gamma-glutamyltransferase Level and Serum Ferritin Level in Healthy Adults
Journal of the Korean Academy of Family Medicine
;
: 645-651, 2006.
Article
in Korean
| WPRIM
| ID: wpr-59223
ABSTRACT
BACKGROUND:
Serum gamma-GT is one of the biliary enzymes with the only enzymatic activity capable of cleaving extracellular glutathione, thus originating precursor amino acids for the intracellular resynthesis of glutathione. Several population-based studies have shown a strong cross-sectional association between serum gamma-GT concentration and cardiovascular risk factors. And prospective studies showed that serum gamma-GT concentration had a prognostic impact on cardiovascular mortality. But, the mechanism by which gamma-GT is associated with cardiovascular disease is not elucidated. We hypothesized that there was an association between serum gamma-GT and ferritin, a marker of oxidative stress. In this study, we investigated the relationship between serum gamma-GT and serum ferritin.METHODS:
By reviewing the medical records of 288 healthy adults, we determined the serum levels of gamma-GT and ferritin according to age, body mass index, systolic blood pressure, diastolic blood pressure, triglycerides, total cholesterol, LDL-cholesterol, fasting blood sugar, hs-CRP, serum ferritin, AST, ALT, uric acid and smoking history. We studied the relationship between the variables by Pearson correlation coefficients and multiple stepwise regression analysis. Mean values of serum gamma-GT according to the smoking history were compared using t-test.RESULTS:
Serum gamma-GT correlated positively with serum ferritin (r=0.42; P<0.001). BMI, triglycerides, total cholesterol, fasting blood sugar, AST and ALT also showed statistically significant correlation. Smokers showed significantly higher serum gamma-GT. Serum gamma-GT correlated with serum ferritin, ALT, current smoking and triglycerides by multiple stepwise regression analysis.CONCLUSION:
Serum gamma-GT correlated positively with serum ferritin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoke
/
Triglycerides
/
Uric Acid
/
Blood Glucose
/
Blood Pressure
/
Cardiovascular Diseases
/
Smoking
/
Body Mass Index
/
Medical Records
/
Cholesterol
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
Language:
Korean
Journal:
Journal of the Korean Academy of Family Medicine
Year:
2006
Type:
Article
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