Differential Gene Expression in Placenta of Term Pregnant Women with and without Labor using cDNA Microarray / 대한주산의학회잡지
Korean Journal of Perinatology
;
: 370-377, 2007.
Article
in Korean
| WPRIM
| ID: wpr-59232
ABSTRACT
OBJECTIVE:
cDNA microarray technology was used to comprehensively analyze the gene expression in the placenta of term women with labor compared to without labor.METHODS:
Placental tissue was obtained from patients in spontaneous labor (n=5) and those not in labor (n=5) during Cesarean section of full term pregnancy. mRNA levels were examined through cDNA microarray using Agilent GeneSpringGX 7.3 (Agilent technology, USA). SPSS 11.0 was used for statistical analysis.RESULTS:
Among total 38,467 genes, 2,374 genes were detected to be up-regulated in labor samples, while 12 genes were down-regulated. 40 genes of them were identified as significantly up-regulated in levels of expression (up-regulated > or =5.0 fold, p<0.05). According to gene ontology analysis, they are associated with variable cell biologic functions including apoptosis, signal transduction, metabolic process, immune response, and transcription, etc.CONCLUSION:
This study suggests that our results could provide interesting clues to understanding the initiation and the process of normal labor and might lead to further studies in a more targeted fashion.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Placenta
/
RNA, Messenger
/
Signal Transduction
/
Gene Expression
/
Cesarean Section
/
Apoptosis
/
DNA, Complementary
/
Oligonucleotide Array Sequence Analysis
/
Gene Expression Profiling
/
Pregnant Women
Limits:
Female
/
Humans
/
Pregnancy
Language:
Korean
Journal:
Korean Journal of Perinatology
Year:
2007
Type:
Article
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