Correlation Between Cervical Cancer and Cervical Virus Infection / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the diagnostic effect of cervical cytology test combined with high-risk human papilloma virus detection in the diagnotic and screening tests for cervical cancer and its precancerous lesion.METHODS To screen 590 women by conventional Papanicolaou smear test combined with oncogenic human papilloma virus DNA testing,selecting the abnormalities and high-risks in clinic,and using vaginoscopical biopsy or cervical canals scraping.We diagnosed patients according to histopathology.RESULTS From 590 patients there were no high risk changes when cytology and human papilloma virus(HPV) were negative;the rate of ≥cervical intraepithelial neoplasia(CIN) Ⅱ was 10.1% when cytology(-) and HPV(+);the rate of ≥CIN Ⅱ was 39.39% when cytology(+) and HPV(+);and the rate of ≥CIN Ⅱ was 12.3% when cytology(+) and HPV(-).There were no CIN Ⅲ or even worse.CONCLUSIONS The way of cytology combined with high risk HPV test is accurate,swift and sensitive,it can be used into screening cervical cancer and its precancerous lesion,futhermore,the screening interval can be lengthened if the results are negative.