Endoscopic metal stents drainage for malignant biliary obstruction / 中国组织工程研究

ABSTRACT

AIM: To evaluate the therapeutic value of endoscopic metal stent implantation for malignant biliary obstruction. METHODS: Clinical data of 212 patients with malignant biliary obstruction undergoing endoscopic biliary drainage were retrospectively analyzed. Based on the clinical and imaging data,malignant biliary obstruction was identified and according to drainage effect of endoscopic nasobiliary drainage and endoscopic retrograde biliary drainage (ERBD),endoscopic metal biliary endoprothesis was conducted and compared with palliative endoscopic drainage and ERBD. RESULTS: The success rate of one-off operation was 99.5%. For jaundice release,68.4% of the cases were satisfactory,27.5% were released,and 4.1% had no effect. The effective rate of jaundice release (satisfactory + release) in obstruction at low site was 96.6% and that at high site was 82.4%. Average duration of obstruction release was 289 days and average survival was 310 days. The complication rate was 6.7% with a mortality rate of 1.2%. CONCLUSION: Based on rigorous indication selection,EMBE is as a safe and effective therapeutic means to remove malignant biliary obstruction. EMBE may replace palliative biliary surgery for patients with mid-late stage biliary tumors.