The clinical significance of lowering the cut-point of impaired fasting glucose:in view of insulin sensitivity and islet ? cell function / 中国糖尿病杂志
Chinese Journal of Diabetes
; (12)2008.
Article
in Zh
| WPRIM
| ID: wpr-592672
Responsible library:
WPRO
ABSTRACT
Objective To evaluate the features of insulin sensitivity and ?-cell function in a Chinese population with normal fasting glucose.Methods 2,388 subjects aged≥20 years were divided into 5 groups based on the results of oral 75-g glucose tolerance test(OGTT):low-NFG,mid-NFG,high-NFG,IFG,T2DM.We compared insulin secretion and insulin sensitivity using several indexes derived from OGTT.Results There was a progressive decline in indexes of ?-cell function and insulin sensitivity when moving from NFG to type 2 diabetes.Compared with subjects with mid-NFG(FPG 4.9~5.6mmol/l),subjects with high-NFG(FPG5.6~6.1mmol/l)were more resistant to insulin,and had reduced insulin secretion,higher plasma triglyceride level and reduced HDL cholesterol concentrations(P
Full text:
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Index:
WPRIM
Type of study:
Diagnostic_studies
Language:
Zh
Journal:
Chinese Journal of Diabetes
Year:
2008
Type:
Article