Progress in intervertebral disc tissue engineering / 中国组织工程研究

ABSTRACT

Intervertebral disc tissue engineering is achieved by means of establishing complete intervertebral disc tissue in vitro and then implanting it to the primary degenerative intervertebral disc,thus conducting the treatment.Nowadays the research mainly focuses on the cultivation of intervertebral disc cell,the selection of the tissue engineering scaffold,the establishment and implantation of the intervertebral disc tissue engineering and so on.Recently there are three common ways to cultivate cell.The cell cultivation under the circumstance of zero-gravity and three-dimension not only accords the human being's natural three-dimensional structure,but also could reduce the mechanical shearing force of the medium and overcome the touching re-striction caused by the gravity sedimentation.It could make cell growth better and that is a new attempt to cultivate intervertebral disc cell.There are many species of scaffold of tissue engineering,and everyone has the advantage and disadvantage.Today none of these scaffold materials are accepted as the most suitable one so that it needs more and more study in these aspects.To establish complete intervertebral disc tissue and conduct implantation have already succeed in animal experiment.It is shown that implant-ing intervertebral disc cell which is cultivated by tissue engineering to degenerative intervertebral disc could partly reverse the degeneration.