Effects of Plumbago zeylanica Linn on fracture healing in rabbits / 中国组织工程研究
Chinese Journal of Tissue Engineering Research
;
(53)2007.
Article
in Chinese
| WPRIM
| ID: wpr-593609
ABSTRACT
BACKGROUND:
The essential component of Plumbago zeylanica Linn is plumbagin, which plays a role in anti-leukemia, antibiosis, antifertility, as well as cardiovascular.OBJECTIVE:
To investigate the effects of Plumbago zeylanica Linn on the healing process of experimental rabbit fracture. DESIGN, TIME ANDSETTING:
Randomized control experiment of animal was performed at the Department of Pharmacology, Guilin Medical College between December 2006 and February 2007. MATERIALS Eight New Zealand rabbits, 80 to 85-day-old, weighing 2.1-2.5 kg, half male and half female.METHODS:
Eight rabbits were randomly divided into the control and experimental groups, with 4 animals in each group. Under sterile conditions, the experimental bone fracture model of rabbit was created by making a longitudinal incision in the medial of the middle portion of right foreleg, cutting off a point-foot radius with bone clamp, and suturing the incision. The rabbits in the experimental group were treated externally with the extraction of Plumbago zeylanica Linn in 50% of ethanol, twice a day for 15 days. The sodium chloride was administrated into rabbits in the control group. MAIN OUTCOMEMEASURES:
The serum alkaline phosphatase (S-ALP), Ca2+, P3+, K+, Na+, Cl-, liberation and total calcium of the rabbit were measured at 15 and 30 days after drug administration, X-ray of the bones were performed at the fracture healing.RESULTS:
Compared with the control group, the fracture healing of the experimental group was faster, and the serum examinations showed that the serum Ca2+ levels of the experimental group was significantly increased by Plumbago zeylanica Linn, there had significantly differences between prior to and after drug administration (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Journal of Tissue Engineering Research
Year:
2007
Type:
Article
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