Resveratrol Attenuated Reactive Oxygen Species in Injured Endothelial Cells / 中华高血压杂志
Chinese Journal of Hypertension
; (12)2007.
Article
in Zh
| WPRIM
| ID: wpr-593803
Responsible library:
WPRO
ABSTRACT
Background Resveratrol has been unanimously recognized as an cardiovascular protective substance in red wine. It has been speculated that the anti-atherosclerosis effect of resveratrol is ascribed to its powerful anti-inflammatory effect. Objective To investigate the effects of resveratrol on injured human umbilical veno-endothelial cells (HUVEC) and the reactive oxygen species(ROS) production induced by TNF-? or soluble CD40L (sCD40L). Methods Cultured HUVEC were pre-incubated with resveratrol(1-50 ?mol/L) for 2 hours and then treated with TNF-?(10 ?g/L) or sCD40L?(10 ?g/L) for another 4 hours. MTT assay was used to detect proliterative activity of HUVEC. Immunofluorescence microscopy was used for determination of ROS expression. Results Both TNF-? and sCD40L impaired HUVEC proliferation (-32.7% and -26% vs control,P
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Index:
WPRIM
Language:
Zh
Journal:
Chinese Journal of Hypertension
Year:
2007
Type:
Article