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Tanshinone ⅡA Inhibit Pressure Load Induced Left Ventricular Hypertrophys and Myocardial JAK1/STAT3 in Rats / 中华高血压杂志
Chinese Journal of Hypertension ; (12)2007.
Article in Chinese | WPRIM | ID: wpr-593804
ABSTRACT
Background Left ventricular hypertrophy(LVH) is a cardiovascular risk factor independent of the blood pressure. JAK/STAT pathway has been confirmed to participate in cardiac hypertrophy and hyperplasia. Our previous reports have shown that sodium tanshinone ⅡA sulfonate(STS) reversed LVH,inhibited the myocardial cells Ca2+ influx,lowered left ventricular myocardial tumor necrosis factor-?(TNF-?)and the proto-oncogene c-fos,Bcl-2,and p53 protein expression. Objective To study the effect of sodium tanshinone ⅡA sulfonate(STS) on JAK/STAT pathway in left ventricular hypertrophy(LVH) induced by abdominal aorta stenosis in rats. Methods Twenty-four 9-weeks-old rats submitted to abdominal aorta constriction,were randomized to receive STS 10 mg/(kg?d)(n=8)or sterilized distilled water (1 mL/d)(n=8),or valsartan 10 mg/(kg?d) by gavage(n=8),with age and sex matched sham operated rats(n=8) as control. HE,VG and immunohistonchemical staining were used to evaluate the myocardial fiber dimension(MFD). Expressions of JAK1 and STAT3 were assessed by using Western blot. Results Compared with the control group,pressure loaded rats had higher SBP[(117.3?8.3) vs LVH (186.5?13.5)mmHg,P

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Risk factors Language: Chinese Journal: Chinese Journal of Hypertension Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial / Risk factors Language: Chinese Journal: Chinese Journal of Hypertension Year: 2007 Type: Article