Drug-resistant Gene and Disinfectant-resistant Gene in MRSA / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To study the drug resistance,drug-resistant genes and disinfectant-resistant genes of clinical MRSA isolates.METHODS The sensitivity to penicillin and other 15 antibacterial agents was detected in 56 strains of MRSA by K-B paper disk diffusion.The mecA gene of the ?-lactamase and disinfectant-resistant genes qac(A/B)were detected by PCR.RESULTS All of the 56 strains of MRSA were sensitive to vancomycin and teicoplanin.Drug resistant rate of sulfamethoxzole/trimethoprim,nitrofurantoin,rifampin,tetracycline,levofloxacin,clindamycin and azithromycin were 17.9%,23.2%,82.1%,87.5%,89.3%,92.9% and 96.4%,respectively.All of the 56 strains were resistant to erythromycin,gentamicin,amikacin,penicillin,ampicillin/sulbactam,cefoxitin and ampicillin.In all 56 strains of MRSA,54(96.4%)MRSA isolates were mecA positive and 31(55.4%)MRSA isolates were qac(A/B)positive.CONCLUSIONS Clinically isolated MRSAs is multi-drug-resistant and the qac(A/B)positive rate is very high.