Telomere length and chronic compartment syndrome in the lumbosacral region / 中国组织工程研究

ABSTRACT

BACKGROUND: There is a close correlation between telomere length and cell senescence, immortalization or canceration. OBJECTIVE: To explore the significance of telomere length diversifies in the chronic compartment syndrome in lumbosacral region. DESIGN, TIME AND SETTING: A comparative observation was performed at the State-Level Key Medical Genomics Laboratory, Shanghai Jiao Tong University School of Medicine from July 2007 to February 2008. PARTICIPANTS: The vertical spinal muscular tissue samples were taken from people aged 29-49 years old [mean aged (34.7?12.6) years] including 10 normal people and 15 patients with chronic compartment syndrome. According to the age, the normal were divided into the aged 30-37, and aged 38-45 groups. The abnormal were divided into aged 29-34, aged 35-43 and aged 44-49 groups, with 5 samples in each group. METHODS: DNA was extracted from samples of each group. Telomere length in vertical organizations spinal muscular skeletal muscle was measured by Southen Blotting hybrid technology. MAIN OUTCOME MEASURES: Telomerase length of erector spinal muscles in patients and normal people. RESULTS: The mean telomere length in patients with chronic compartment syndrome was obvious shorter than that of the normal people, which has significant difference (P