Expression of Clusterin in colorectal cancer tissues and its relationship with clinicopathological properties / 中国肿瘤生物治疗杂志

ABSTRACT

Objective:To observe the expression of Clusterin in colorectal cancer tissues and study its relationship with the development and progression of colorectal cancer.Methods:Fifty-eight colorectal cancer tissues samples(32 rectal cancer tissues,26 colon carcinoma tissues) of patients with completed clinic data were obtained after surgery from the Affiliated Hospital of Guangdong Medical College.Immunohistochemical staining(SP method) was used to detect the expression of Clusterin in colorectal cancer tissue,adjacent normal tissue of colorectal cancer and normal tissue.Flow cytometry was used to examine the apoptosis of colorectal cancer cells.Results:The expression of Clusterin in colorectal cancer tissues was significantly higher than those in the adjacent tissues of colorectal cancer and normal colorectal tissue(P