Effects of limbs ischemic postconditioning on mitochondria structure and function after cerebral ischemic reperfusion in diabetic rats / 临床神经病学杂志
Journal of Clinical Neurology
;
(6)1992.
Article
in Chinese
| WPRIM
| ID: wpr-594035
ABSTRACT
Objective To investigate effects of limbs ischemic postconditioning induced remote postconditioning (RPostC) on mitochondria structure and function after focal cerebral ischemic reperfusion(I/R) injury in diabetic rats. Methods The diabetic rats models were induced by injecting streptozotocin into abdominal cavity. I/R rats models were made by MCAO with thread. Forty male SD rats models were assigned to 4 groups control group; sham operation group; I/R group;RPostC group ( n=10 ) . 6 h after the reperfusion, the brains were obtained for HE staining. The mitchondria were isolated and content of MDA,the activities of SOD,Na+/K+-ATPase,Ca2+-ATPase and GSH-Px were tested. Morphological changes of neuronal mitochondria were observed by electronic microscope. Results In the I/R group,the content of mitchondria MDA[(4.99?1.25) nmol/mgprot]were markedly increased (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Clinical Neurology
Year:
1992
Type:
Article
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