Escherichia coli:Distribution and Resistance Analysis / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the distribution and resistance characteristic of Escherichia coli in order to provide reference for the clinical application of drugs.METHODS The strains of E.coli were detected and their sensitivity to antibiotics was determined by VITEK automatic bacterium identifying and drug sensitivity analyzing systems,then the specimens in which E.coli was detected and the result of sensitivity to antibiotics were analyzed.RESULTS Among 210 specimens in which E.coli was detected,the urine was the most frequent.There were 46 strains which produced extended-spectrum ?-lactamases(ESBLs),the ESBLs-producing rate of E.coli was 21.9%,the drug resistance of ESBLs producers was more serious than that of nonproducers.The resistant rate of ESBLs producers against penicillins was 100%,but the susceptibility rate was 19.6-84.8% while combined with the ?-lactamases inhibitors.The susceptibility rates of ESBLs producers to the antibiotics from the first generation cephalosporins to the third generation ones were 0.0-45.6%.The susceptibility rates of ESBLs producers to cefepime,cefoxitin,ciprofloxacin and Cotrimoxazole were 60.9%,34.8%,10.9% and 13.0%,respectively,whereas amikacin,imipenem,and meropenem were more effective against the bacteria,the susceptibility rates of ESBLs producers were 89.1%,97.8% and 97.8%,respectively.while all the nonproducers were susceptible to them.The ESBLs producers had high sensitivity to imipenem,meropenem,amikacin and piperacillin/tazobactam,and had high resistance to the other antimicrobial drugs,they showed multi-drug resistance.CONCLUSIONS It is rather serious the resistance of E.coli to usual antibiotics,and that of ESBLs producers is more serious.It should be cautious to use cephalosporins to treat infections caused by E.coli,carbapenem,amikacin and some of complex antibiotics containing ?-lactamases inhibitor are very effective to treat infections caused by ESBLs producers.It is very important to select rational drugs correctly for clinical treatment of the infections according to the results of antibiotics susceptibility tests.