Plasma Lipids and Apolipoproteins as Risk Factor of Ischemic Heart Disease
Korean Circulation Journal
;
: 229-239, 1991.
Article
in Korean
| WPRIM
| ID: wpr-59420
ABSTRACT
Recent studies suggest that apolipoproteins may be better predictor of ischemic heart disease than are plasma lipids, such as total cholesterol and high density lipoprotein cholesterol(HDL-C). To examine this hypothesis, plasma levels of major lipids and major apolipo-proteins were measured and their derivatives were calculated in 30 male patients with ischemic heart disease(16 angina pectoris and 14 old myocardial infarction) and 30 age-matched male healthy controls. Plasma levels of lipids were obtained by conventional methods and apolipoproteins by Rocket immunoelectrophoresis. Levels of HDL-C, HDL2-cholesterol(HDL2-C), and apolipoprotein-AII, and ratios of HDL-C/total cholesterol, HDL2-C/total cholesterol, and apolipoprotein-AI/apolipoprotein-B were lower in the group of patients than in controls. Levels of low density lipoprotein cholesterol(LDL-C) and apolipoprotein-B, and ratios of lDL-C/HDL-C and apolipoprotein-AI/apolipoprotein-AII were higher in the group of patients. There were no statistically significant differences in the levels of total cholesterol and apolipoprotein-AI between the two groups. Stepwise discriminators analysis showed that apolipoprotein-B and apolipoprotein-AII were better discriminators than plasma lipids for identifying those with ischemic heart disease. One could correctly classify 78% of the cases by using the levels of the two apolipoproteins. By using the level of apolipoprotein-B, one could correctly classify 73% of the cases. There were no correlations between the levels of total cholesterol and HDL-C in the controls whereas there were positive correlations between the levels in the group of patients. In conclusion, this study showed that apolipoprotein-B was the best single discriminator for identifying the patients with ischemic heart disease, followed by apolipoprotein-AII.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins
/
Apolipoproteins A
/
Plasma
/
Immunoelectrophoresis
/
Cholesterol
/
Risk Factors
/
Myocardial Ischemia
/
Heart
/
Angina Pectoris
/
Lipoproteins
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
Korean
Journal:
Korean Circulation Journal
Year:
1991
Type:
Article
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