Relationship between smooth muscle cell hyperplasia and plasma tissue factor after percutaneous coronary intervention in porcine model / 中国介入心脏病学杂志

ABSTRACT

Objective To discuss the relationship between plasma levels of tissue factor(TF) in the circulation and the development of smooth muscle cells(SMC) hyperplasia after percutaneous coronary intervention(PCI) in porcine models.Methods Thirty swines were used and their coronary arteries were injured by balloon dilatation.Morphological measurements included neointimal area and the extent of area stenosis.Plasma TF level was measured before and after PCI.The relationship between TF and neointimal area was calculated.Results Different degrees of intimal hyperplasia were found among all vessels and the rate of restenosis was 60%.Plasma TF levels were significant higher in vessels which subsequently developed restenosis(30 minutes after PCI 688.36?91.57 ng/L vs 514.87?68.73 ng/L,24 hours after PCI 706.09?89.59 ng/L vs 539.22?70.51 ng/L,P