Drug Resistance of Aminoglycoside-resistant Klebsiella pneumoniae / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the antimicrobial-resistant profile of aminoglycosides-resistant Klebsiella pneumoniae isolated from Wenzhou.METHODS Between Jan 2006 and Sep 2007,non-replicate clinical isolates of K.pneumoniae were consecutively collected from inpatients in a teaching hospital in Wenzhou,China.Antibiotic susceptibility test was determined by the disc diffusion method recommended by CLSI.Sixty-four gentamicin-resistant isolates were investigated for the presence of ESBLs by the CLSI-recommended confirmatory tests.RESULTS Of the 64 gentamicin-resistant isolates,the resistant rates to ciprofloxacin,levofloxacin cefoxitin,tetracycline,trimethoprim/sulfamethoxazole,ceftazidime and cefotaxime were 7.5%,29.7%,39.1%,85.9%,76.6%,67.2%,and 73.4%,respectively.All isolates were susceptible to imipenem.73.4% of gentamicin-resistant isolates produced ESBLs.CONCLUSIONS Gentamicin-resistant K.pneumoniae is multi-resistant to antibiotics.