Oral Chlorhexidine on Ventilator-associated Pneumonia / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To evaluate the oral decontamination effect of chlorhexidine on ventilator-associated pneumonia. METHODS One hundred and eight patients needing mechanical ventilation were randomly divided into two groups.This was a double-blind and placebo-controlled trial.Placebo group decontaminated oral cavity with saline and test group with 0.5% chlorhexidine.Finally we compared difference of the incidence of VAP,oropharyngeal colonization and endotracheal colonization between two groups. RESULTS There were no statistic differences between two groups in the age,gender,constituent ratio of underlying disease,APACHEⅡ and clinical pulmonary infection scores(CPIS).The incidence of VAP,early onset VAP,oropharyngeal colonization and endotracheal colonization in test group was statistically lower than those in placebo group. CONCLUSIONS Oropharyngeal decontamination with chlorhexidine reducg and delays the development of VAP in patients receiving mechanical ventilation.It is a safe and effective antiseptic solution in oral care.