Effect of Botulinum Toxin A Injection into the Salivary Glands for Sialorrhea in Children with Neurologic Disorders
Annals of Rehabilitation Medicine
;
: 340-346, 2012.
Article
in English
| WPRIM
| ID: wpr-59512
ABSTRACT
OBJECTIVE:
To determine the 9 month period effect of botulinum toxin A (BoNT-A) injection into the salivary gland in children with neurologic disorders and sialorrhea by qualified parent/caregiver-administered questionnaires.METHOD:
A total of 17 patients (age 7.6+/-4.24 years) were enrolled in this study. The degree of sialorrhea was assessed at the baseline, 2 weeks, 1, 2, 4, 6 and 9 months after injection. The Drooling Count (DC) was assessed as an objective measurement. The Drooling Frequency and Severity Scale (DFS) and the Teacher Drooling Scale (TDS) were evaluated as a subjective measurement. BoNT-A (0.5 unit/kg) was injected into each submandibular and parotid gland under ultrasonography-guidance.RESULTS:
DC, DFS and TDS showed significant improvement at 2 weeks, 1, 2, 4, 6, and 9 months follow-up (p<0.05). Twelve of 17 cases (70.5%) showed more than 50% reduction in DC from the baseline value.CONCLUSION:
Ultrasonography-guided BoNT-A injection into the submandibular and parotid gland was a safe and effective method to treat sialorrhea in children with neurologic disorders.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Parotid Gland
/
Salivary Glands
/
Sialorrhea
/
Sorbitol
/
Botulinum Toxins
/
Tyramine
/
Follow-Up Studies
/
Botulinum Toxins, Type A
/
Nervous System Diseases
Type of study:
Observational study
/
Prognostic study
/
Qualitative research
Limits:
Child
/
Humans
Language:
English
Journal:
Annals of Rehabilitation Medicine
Year:
2012
Type:
Article
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