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Telmisartan Reduce Serum Retinol Binding Protein 4 and Improve Insulin Resistance in Rats with Metabolic Syndrome / 中华高血压杂志
Chinese Journal of Hypertension ; (12)2007.
Article in Chinese | WPRIM | ID: wpr-595193
ABSTRACT
Background Retinol binding protein 4(RBP4) is a novel adipokine which has been related with insulin resistance.Objective To test the hypothesis that telmisartan improves glucose and lipid metabolism may be associated with inhibiting serum RBP4 and phosphoenolpyruvate carboxykinase activity in liver.Methods Thirty wistar male rats were received high fat diet to establish metabolic syndrome model and randomly to receive telmisartan [5 mg/(kg?d),n=8] or pioglitazone [20 mg/(kg?d),n=8] for 8 weeks or high-fat diet placebo(n=10).Plasma triglyceride(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),fasting plasma insulin,serum RBP4,and phosphoenolpyruvate carboxykinase specific enzyme activity in liver(PEPCK) were determined.Results Telmisartan improved insulin resistance and the disorders of glucose and lipid metabolism in diet-induced insulin resistance rats [HOMA-IR,telmisartan group(3.4?1.2) vs high-fat diet group(8.3?1.1),P

Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial Language: Chinese Journal: Chinese Journal of Hypertension Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Type of study: Controlled clinical trial Language: Chinese Journal: Chinese Journal of Hypertension Year: 2007 Type: Article