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Preparation of arbidol hydrochloride multi-layers controlled-released and evaluation of its release rate in vivo and in vitro / 吉林大学学报(医学版)
Journal of Jilin University(Medicine Edition) ; (6)2006.
Article in Chinese | WPRIM | ID: wpr-595389
ABSTRACT
Objective To study the development of Arbidol hydrochloride(Ahyd) multi-layers controlled-released preparation and evaluate its release rate in order to provide the basis for Ahyd pharmacodynamics reseach.Methods Ahyd multi-layers was used as experiment group and Ahyd single-layer as control,high performance liquid chromatography(HPLC) was used to examine releasing level of two groups for calculating parameters of drug metabolism and bioavailability.Results Compared with Ahyd single-layer,the multi-layers controlled-released preparation had several significant advantages as belowCmax fell remarkably(P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Jilin University(Medicine Edition) Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Jilin University(Medicine Edition) Year: 2006 Type: Article