The effects of Nutrison on rat gut barrier after 5-FU chemotherapy / 国际外科学杂志

ABSTRACT

Objective To investigate and assess the effects of nutrison on rat gut barrier after 5-FU chemo-therapy. Methods Thirty male Sprague-Dawley rats were randomly assigned to three groups EN group nutrison intestinal nutrition; STD group nutrison intestinal nutrition + chemotherapy; CHOW group chow+ chemotherapy. The changies such as weight, lactulose / mannitol of urine samples before and after chem-otherapy were observed. At the 8th day, colon as well as jejunum tissue were also sampled for pathological examination to measure the height of jejunum villi, the thickness of colon and jejunum. Results Compared to EN group, the body weight the height of jejunum mucosa and the thickness of colon / jejunum loss of STD group was significantly decreased, as well as the L/M inceased. The data showed that CHOW group was bet-ter than EN group. Conclusions Intraperitoneal injection of 5-FU increased the intestinal permeability of rats and damaged the function of intestinal barrier. The intestinal mucosal protection effect of nutrison EN in post-chemotherapy rats was weaker than the effect of a free-eating group.