Protective effects of polyphenols of vitis amurensis Rupr on rat oxidative damage caused by chronic alcohol intakes / 吉林大学学报(医学版)
Journal of Jilin University(Medicine Edition)
;
(6)2006.
Article
in Chinese
| WPRIM
| ID: wpr-595413
ABSTRACT
Objective To study the protective effects of the polyphenols of vitis amurensis Rupr(PVAR) on oxidative damage in rats caused by chronic alcohol intakes.Methods Forty male Wistar rats were divided into 4 groups according rats' weights normal control group,alcohol injury group(the rats were treated with 10 mL?kg-1 33% alcohol via i.g);PVAR group(after ingesting 200 and 400 mg?kg-1 PVAR,the male rats were treated with 10 mL?kg-1 33% alcohol via i.g).After 8 weeks,the concentrations of malondialdehyde(MDA),reactive oxygen species(ROS),glutathione(GSH) and the activities of SOD and heme oxygenase-1(HO-1) in rat liver tissues were measured.The activities of serum glutamic-pyruvic transaminase(GPT) and glutamic oxaloacetic transaminase(GOT) in rats were measured.Results Compared with alcohol injury group,the concentrations of MDA,ROS,GPT and GOT were decreased significantly(P
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Jilin University(Medicine Edition)
Year:
2006
Type:
Article
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