Syphilis Detection in High-risk Groups with Combined Serological Method / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate syphilis serology detection methods suitable for high risk group. METHODS Treponema pallidum(TP-ELISA) and toluidine red un-hoated serum test(TRUST) combined screening methods were taken for sexually transmitted disease(STD) patients and suspicious cases with dirty sexual intercourse,and all the positive results were further confirmed by TPPA method. RESULTS The detection rate of TP-ELISA or TRUST method alons was 18.3% or 13.7%,respectively.The detection rate of the both methods was 20.8%.A percent of 12.0% in 108 cases that were detected positively by the combined screening methods were proved to be false positive by TPPA. CONCLUSIONS The combined screening methods of TP-ELISA and TRUST can reduce the escaping rate,while TPPA can exclude the false positive cases in screening period.Sensitivity and accuracy of syphilis detection can be ensured by taking TP-ELISA and TRUST combined screening with TPPA confirmation methods,which are without high cost and suitable for high risk group.