Nosocomial Infections in Advanced Lung Cancer Patients During and after Chemotherapy:An Incidence Survey and Risk Factor Analysis / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the clinical characteristics and risk factors of nosocomial infection in advanced lung cancer patients during and after chemotherapy. METHODS A retrospective analysis of 119 cases suffered from nosocomial infections from 628 cases with lung cancer was made. RESULTS The nosocomial infection rate was 18.9%.The most common infection site was respiratory tract,followed by gastrointestinal and urinary tracts.The ratio of G-bacilli to total bacteria examined was 49.5%,and the bacilli were mainly Pseudomonas aeruginosa,followed by Escherichia coli.The ratio of G +bacilli and fungi to total bacteria examined were 27.8% and 22.7%,respectively. CONCLUSIONS It is found that the risk factors of nosocomial infection in lung cancer patients are central type of lung cancer,retreated patients,hypoalbuminosis,lower CD4 +/CD8 + ratio,invasive operation,time of using broad-spectrum antibiotics and longer hospital stay and the higher risk factors are grades 3-4 neutropenia and infections due to accompanying persons.