Research progresses in differentiation of induced pluripotent stem cells / 国际生物医学工程杂志

ABSTRACT

Research on the in vitro differentiation of embryonic stem cell(ES) is one of the hotspots in the study about developmental biology and cell transplantation therapy. But ethical issues and immune rejection remained to be the reasons which obstruct the progress. Recently, scientists have successfully obtained a kind of phripotent stem cell named induced phripotent stem cells (iPS). Since iPS posses similar properties with ES and can be autologously derived from patients themselves, it is a potential substitute of ES beth in the basic research and clinical application and the above mentioned problems can be avoided. However, iPS must differentiate to specific cells before being used in the clinical therapeutic research. The present article provides a concise summary of current progress on the differentiation ofiPS cell as well as some existing problems.