Nasopharyngeal Carcinoma in Children and Adolescents: Single Institution Study / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 114-120, 2014.
Article
in English
| WPRIM
| ID: wpr-59585
ABSTRACT
BACKGROUND:
Nasopharyngeal carcinoma (NPC) is very rare in children and adolescents. The aim of this study was to evaluate clinical characteristics and treatment outcomes of pediatric NPC.METHODS:
Medical records of 9 patients treated for NPC at the Seoul National University Children's Hospital between 1988 and 2012 were analyzed retrospectively.RESULTS:
The median age at diagnosis was 11 years (range, 9-13 years). One patient had stage II disease, 3 had stage III disease, and 5 had stage IV disease. The histologic subtypes were undifferentiated carcinoma and squamous cell carcinoma in 7 and 2 patients, respectively. All patients were initially treated with cisplatin (100 mg/m2 intravenous [IV] every 4 weeks for 4-6 months), bleomycin (15 unit/m2 IV every 1 weekx7), and fluorouracil (1,000 mg/m2 IV every 4 weeks for 1 year). Eight patients received radiotherapy with doses of 45-59.4 Gy at the primary site and neck nodes. Seven patients (77.8%) achieved complete remission, 1 (11.1%) achieved partial remission, and 1 (11.1%) showed disease progression. Six patients developed fluorouracil-related neurotoxicity; the regimen was changed to cisplatin, epirubicin, and bleomycin in five of the 6 patients. One patient died of progressive disease without responding to treatment. Treatment-related mortality occurred in 1 patient owing to septic shock. Secondary osteosarcoma developed in 1 patient 6 years after treatment. The overall survival was 77.8%, with a median follow-up of 40.8 months (range, 4.5-287.6 months).CONCLUSION:
Children and adolescents with advanced NPC treated with combined chemotherapy and radiotherapy have a good survival rate.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pediatrics
/
Radiotherapy
/
Shock, Septic
/
Bleomycin
/
Carcinoma
/
Carcinoma, Squamous Cell
/
Epirubicin
/
Osteosarcoma
/
Nasopharyngeal Neoplasms
/
Medical Records
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Child
/
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS