Correlation of MMP and TIMP with osteosarcoma invasion and metastasis / 医学研究生学报
Journal of Medical Postgraduates
;
(12)2003.
Article
in Chinese
| WPRIM
| ID: wpr-595872
ABSTRACT
Matrix metallopmteinase(MMP),a family of proteolytic enzymes,can degradate the composition of extracellular matrix.Its structure,regulatory function and physiopathology have been deeply studied,and its role in tumor metastasis has received more attention.The tissue inhibitor of metalloproteinase(TIMP),as an endogenous MMP inhibitor,suppresses both the form and course of MMP activation.The function zone of its C-end accords with some other parts of MMP,forming an MMP-TIMP compound,to block the combination of MMP with the substrate,suppress the activation of MMP,and slow down or block the invasion and metastasis of osteosarcoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2003
Type:
Article
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