Flora Distribution and Drug-resistance in Tumor Patients with Deep Fungal Nosocomial Infection / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To approach the flora distribution and drug-resistance status in deep fungal nosocomial infection in tumor patients and offer scientific evidence of prevention and controlling of it.METHODS Retrospective reviews were performed to analyze the 153 cases of deep fungal nosocomial infections in tumor department.Fungal cultivation,identification and susceptibility tests were performed strictly according to Rules of Operation in Clincal Laboratory of Nationwide.RESULTS The lower respiratory tract was the main site in deep fungal nosocomial infection in tumor patients,accounting for 61.4%.The digestive tract infection rated the second,accounting for 13.1%.Pathogenic bacteria mainly included Candida albicans(60.1%)and C.tropicalis(20.9%).The susceptibility test showed that the drug-resistance rate to amphotericin B and nystatin were all 0 and that to itraconazole and clotrimazole was 0-7.6%.The resistance rate(17.4-30.0%) to fluconazole showed upgrading tendency.CONCLUSIONS We should think highly of etiological detection and monitoring of drug-resistance in deep fungal nosocomial infections in tumor patients in order to control the infections effectively.