Protective effects of estrogen on function of learning-memory and neuron of hippocampus in ovariectomized rats / 临床神经病学杂志
Journal of Clinical Neurology
;
(6)2001.
Article
in Chinese
| WPRIM
| ID: wpr-596226
ABSTRACT
Objective To study the protective effects of estrogen on function of learning-memory and the neuron of hippocampus in the ovariectomized(OVX) rat model.Methods Estrogen 200 ?g/kg was injected into rats twice a weak followed the OVX rat models were estestablished(OVX+E2 group).The function of learning-memory was tested by Morris water maze;the tau hyperphosphorylation was detected by immunohistochemistry staining;the pathological changes of hippocampus was observed by HE staining and Bielschowski staining.Results Compared with OVX group,the function of learning-memory of Morris water maze in OVX+E2 group were significant improved(all P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Clinical Neurology
Year:
2001
Type:
Article
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