Prevalence of Antimicrobial-resistant to Tazocin Enterobacteriaceae Isolated from Blood / 中华医院感染学杂志

ABSTRACT

OBJECTIVE To investigate the prevalence of antimicrobial-resistant to(piperacillin/tazobactam Tazocin) enterobacteriaceae bacteria isolated from blood.METHODS Enterobacteriaceae isolates were isolated from blood specimens in our hospital from Jan 2003 to Dec 2008.The identification of Enterobacteriaceae isolates was performed by VITEK-32 Full Automated Microbiology Analyzer.Antimicrobial susceptibility test was determined by K-B disk diffusion test.RESULTS A total of 344 strains of Enterobacteriaceae isolates were obtained from blood,including 175 strains(50.9%) of Escherichia coli,129 strains(34.9%) of Klebsiella pneumoniae,39 strains(11.3%) of Enterobacter cloacae and 10 strains(2.9%) of Proteus mirabilis.The resistant rate of Enterobacteriaceae isolates to Tazocin was 15.1%.The resistant rates of E.coli,K.pneumoniae and E.cloacae to Tazocin were 16%,16.7%and 10.3%,but all isolates of P.mirabilis were sensitive to Tazocin.The resistant rates of E.coli and K.pneumoniae to Tazocin increased from 9.1% and 8.0% in 2005 to 22.7% and 21.6% in 2008.CONCLUSIONS Most of isolates including E.coli and K.pneumoniae are detected from blood.Tazocin has high antimicrobial activity for Enterobacteriaceae bacteria.The resistance of E.coli and K.pneumoniae to Tazocin is increasing gradually.