Effects of Yunnan Baiyao on inflammatory response and satellite cell regeneration after acute injury of skeletal muscle in rats / 吉林大学学报(医学版)

ABSTRACT

Objective To study the effects and mechanism of Yunnan Baiyao on the inflammatory response and satellite cell regeneration after acute injury of skeletal muscle in rats. Methods Rat models of skeletal muscle injury (gastrocnemius,fast twich;soleus,slow twich) induced by treadmill were constructed 24 h after establishment of the models,the left sides of hind limbs in rats were treated with Yunnan Baiyao,and the right sides were treated with saline at the equal volume.4 rats were chosen 2,4,7,10,14 d after injury,respectively,and gastrocnemius and soleus of the treated sides (the left sides) and untreated sides (the right sides) from hind limbs of 4 rats were obtained,and stained with immunohistochemistry and HE. The quantity and morphological changes of inflammatory cells and satellite cells were observed under optical microscope. Results Compared with untreated sides,the number of inflammatory cells of fast twich after injury in the treated sides was decreased obviously at the 2nd,4th,7th day after injury(P