Relationship between slow coronary flow and endothelial disorder / 中国介入心脏病学杂志

ABSTRACT

Objective To study the relationship between slow coronary flow and endothelium disorder.Methods One hundred and twelve patients with normal coronary angiography were divided into the slow flow group(n=38)and the normal flow group(n=84)in terms of their TIMI frame counts.Risk factors including sex,age,cholesterol,hypertension,diabetes,history of smoking and blood levels of endothelium-1,nitric oxide and interleukin-6 were compared between the 2 groups.Results Slow coronary flow was more common in male than in female(45 vs 39).Patients who smoked showed a higher incidence of slow coroany flow than non-smoker patients(P=0.010).The blood levels of ET-1(108.42?0.81 pg/mL vs 84.74?39.16 pg/mL,P=0.001)and IL-6(158.28?178.86 pg/mL vs 108.07?84.43 pg/mL,P=0.019)was higher in the slow flow group but with a lower levels of NO(35.66?12.28 ?mol/L vs 42.74?17.51 ?mol/L,P=0.032)when compare with the nomal coronary folw group.Conclusion Slow coronary flow is related to endothelium disorder but other risk factors should also be taken into consideration.