Polymorphism of CTLA-4 gene in SLE patients and its association with ANA or anti-dsDNA antibody / 临床检验杂志
Chinese Journal of Clinical Laboratory Science
; (12)2006.
Article
in Zh
| WPRIM
| ID: wpr-596947
Responsible library:
WPRO
ABSTRACT
Objective To investigate the association between systemic lupus erythematosus(SLE) and polymorphism of cytotoxic T-lymphocyte antigen 4 gene(CTLA-4) and the effect on ANA and anti-dsDNA antibody.Methods The A/G substitution was investigated in the exon 1 position 49 in 92 SLE patients and 60 controls by PCR restriction fragment length polymorphism(PCR-RFLP).ANA and anti-dsDNA antibody were examined by indirect fluorescence immunoassay.Results SLE patients had significantly higher frequencies of the CTLA-4+49GG allele than controls(P
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WPRIM
Language:
Zh
Journal:
Chinese Journal of Clinical Laboratory Science
Year:
2006
Type:
Article