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Therapeutic effect of creatine phosphate in early diastolic dysfunction / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine ; (6): 501-506, 2010.
Article in English | WPRIM | ID: wpr-596982
ABSTRACT

Objective:

To investigate the therapeutic effect of creatine phosphate sodium (CP, Neoton) at early stage of myocardium diastolic dysfunction.

Methods:

A total of 138 cases with myocardium diastolic dysfunction were divided into CP group (n=109) and routine treatment group (n=29). All the patients received routine treatment. The CP group received CP treatment based on routine treatment(CP 2g+5%glucose or 0.9% sodium chloride 100ml, iv. drip, for patients with mild diastolic dysfunction was 1time/d, patients with moderate diastolic dysfunction was 2 times/d), duration was 7~14 days. Color-coded Doppler echocardiography was used to detect transmitral peak early diastolic velocity (E-wave),transmitral peak late diastolic velocity (A-wave),peak early diastolic velocity of mitral annulus (Ea), and peak late diastolic velocity of mitral annulus(Aa), and the value of E/A ,Ea/Aa and E/Ea were calculated. Symptoms, signs and items from echocardiography were compared between the two groups before and after treatment.

Results:

After treatment, all symptoms and signs of patients in two groups significantly improved (P<0.05~0.01), and the marked effective rate in CP group was significantly higher than that of routine treatment group (96.2% vs. 57.1%, P<0.01). In CP group, the marked effective rate of E/A (81.65% vs. 10.34%), Ea/Aa (83.49% vs. 13.79%) and E/Ea (92.86% vs. 12.00%) were significantly higher than those in routine treatment group (P<0.01all).

Conclusion:

Creatine phosphate possesses marked effect for improve patient’s condition and diastolic dysfunction.

Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: English Journal: Chinese Journal of cardiovascular Rehabilitation Medicine Year: 2010 Type: Article