Progress in the relationship between P-glycoprotein and refractory epilepsy / 国际儿科学杂志

ABSTRACT

The research of epilepsy drug-resistant mechanism has been paid more and more attention. Pglycoprotein(Pgp) ,being one of the hot points of recent research,plays the transporting role in the body,and its coding genetic polymorphism also affects its expression. The relationship between Pgp and drug-resistant epilepsy is reviewed based on the coding genetic polymorphisms, multidrug transporters hypothesis, concentration equilibrium transport assay, and Pgp inhibition effect.