Influence of pdx1 gene and its epigenetic modification upon pancreatic development and β-cell function / 国际儿科学杂志
International Journal of Pediatrics
;
(6): 588-590,593, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-597184
ABSTRACT
The development of embryo has close relation with the occurrence of type 2 diabetes in adulthood and is attracting increasingly more attention recently. Pancreatic and duodenal homeobox 1 ( pdx1 )expresses in all stages of β-cell development and in mature β cells. As a transcription factor,pdx1 plays a critical role in the formation of whole pancreas,especially in the development and function of β-cell in fetal period,and it is also necessary for the maintenance of mature β-cell function. However, changes in epigenetic modification can alter the expression of pdx1, and then influence pancreatic development and β-cell function . We will make a summary about pdx1 gene structure, function, regulation ,epigenetic modification and so on.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
International Journal of Pediatrics
Year:
2010
Type:
Article
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