Influence of exercise training and angiotensin-converting enzyme inhibitor on blood pressure, aortic compliance and cardiovascular tissue in spontaneously hypertensive rats / 心血管康复医学杂志

ABSTRACT

Objective: To explore influence of exercise training and angiotensin-converting enzyme inhibitor (perindopril) on blood pressure, aortic compliance and cardiovascular tissue structure in spontaneously hypertensive rats (SHR). Methods: A total of 38 SHR aged seven weeks were divided into control group (C group, n=9), exercise group (Exe group, n=9), perindopril group (Per group, n=10) and perindopril + exercise group (Per＋Exe group, n=10). SHRs were observed for eight weeks, and tail-cuff method was used to measure systolic blood pressure（SBP）once a week. When rats were 15 weeks old, regression line（once linear function）was obtained by single regression analyzing the relation between blood pressure and pulse wave velocity（PWV）. The b of this once linear function was used as index of aortic compliance（there was negative relationship between b and aortic compliance）. The left ventricular mass （LVM）/body weight（BW）was used to evaluate ventricular thickening, and aortic weight （AO）/ BW was regard as index of vascular thickening. Results: Compared with C group, SBP of Exe group significantly decreased on 12 weeks old (P0.05）. On 15 weeks old, the LVM/BW [(2.19±0.36) mg/g, (2.16±0.32) mg/g ] and AO/BW [(0.20±0.01) mg/g, (0.19±0.01) mg/g] of Per group and Per+ Exe group significantly decreased compared with C group [(2.95±0.58) mg/g, (0.26±0.01) mg/g], P<0.05 all, but there was no significant difference in these indexes between Per group and Per+ Exe group and between C group and Exe group（P＞0.05 both）. The b （index of aortic compliance）were [（C group ：（21.2±1.2）, Exe group：（20.5±1.4）, Per group：（14.8±1.6），Per＋Exe group：（15.0±1.3）] respectively, there was no significant difference between Per group and Per+ Exe group and between C group and Exe group（P＞0.05 both）. Conclusion: The exercise training of eight weeks possesses certain lowering blood pressure tendency, but no significant influence yet for aortic compliance and cardiovascular tissue structure in spontaneously hypertensive rats.